LIFmediated signal cascades

LIF belongs to the family of IL-6-type cytokines which includes oncostatin M (OSM), ciliary neurotrophic factor (CNTF), interleukin 11 (IL-11), interleukin 6 (IL-6) and cardiotrophin 1 (CT1). These cytokines have diverse and often overlapping effects on a multitude of cell types. The receptors for members of this cytokine family consist of a cyto-kine-specific ligand-binding chain and the shared gpl30 signal transducer chain, which explains the functional redundancy. Downstream of gpl30, two signal-transducing pathways have been recognized, the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and the Ras/mitogen-activated protein kinase (MAPK) pathway. Both pathways are rapidly activated by LIF in various cell types. In addition, the tyrosine kinases Tec, Fes, Btk

Table 1 Synonyms of LIF

Acronym Name Defining action

Table 1 Synonyms of LIF

Acronym Name Defining action

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