Lymphoid and epithelial 78 cells

The anatomical representation of y8 cells varies strikingly. In adult mice, y8 cells account for - 1-3% of T cells in spleen and lymph nodes, 10-50% of intestinal intraepithelial T cells, the majority of reproductive epithelial T cells, and &95% of resident epidermal T cells. In humans, y8 cells usually account for from 0.5% to 15% of T cells in peripheral blood, are variably represented in the gut epithelium, but are not obviously present in the skin. In chickens, y8 cells frequently comprise 30% of peripheral T cells, and can constitute the majority of gut intraepithelial T cells. In ruminants, 30-80% of blood T cells are 78 cells.

A high proportion of 78 cells are double negative (lack surface CD4 and CD8) (see Tables 3 and 4), reflecting the fact that 78 cells generally do not pass through positive selection by class I or class II MHC. Many gut 78 cells are CD8+, but express the CD8ota homodimer that may be unrelated to recognition of class I MHC.

Murine epidermal 78 cells can recognize kera-tinocytes, and gut 78 cells may recognize gut epithelial cells. Epithelial cells acting as antigen-presenting cells would be relatively immobile, providing for few encounters with T cells. Thus, if the T cells are to be activated, those few encounters must have high chance of presenting a 78 TCR ligand. This concept provoked the idea that intraepithelial 78 T cells would have limited antigen specificity, strikingly borne out in the murine skin and reproductive epithelia.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment