Migration inhibition activation and resolution

Chemotactic signals are naturally self-limiting, since they have a narrow range of optimal concentrations for chemotactic activity. When chemotactic factors are present at high concentrations, they tend to activate target cells, resulting in dramatic changes in cellular physiology and in the repertoires of adhesion molecules displayed on the cell surface. Since the release of chemoattractants from a proinflammatory site results in a concentration gradient away from the site, leukocytes first encounter low, chemotactically active concentrations and as they migrate up the gradient, the cells reach concentrations which

a Chemokines

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