Migratory routes of lymphoblasts

After presentation of the respective antigen and appropriate costimulation, naive lymphocytes become lymphoblasts and start proliferation. The traffic of proliferating large lymphoid cells shows a different pattern. Most typically, after injection immunoglobulin A (IgA) lymphoblasts from thoracic duct, Peyer's patches or mesenteric lymph nodes are preferentially found in the lamina propria of the gut. In addition, injected lymphoblasts from the gut-associated lymphoid tissue, but not from peripheral lymph nodes, are found preferentially in organs with mucous layers, such as the bronchial tract, lacrimal, salivary and mammary glands. It has to be stressed, however, that it s a preferential and not an exclusive location.

Phases

Entry

Time

Transit

Exit

Time

Entry

Transit

Exit

Figure 2 Different steps in lymphocyte migration. The mechanisms involved in lymphocyte adhesion to endothelium are known in considerable detail, although lasting only in the range from seconds to minutes. In contrast, the regulation of lymphocyte migration during transit and exit are not well understood, although these phases last for hours, leaving time for intensive interaction with the extracellular matrix (ecm), fibro-cytes (fc), macrophages (mac), dendritic cells (dc) and various chemokines (ch) and cytokines.

Figure 2 Different steps in lymphocyte migration. The mechanisms involved in lymphocyte adhesion to endothelium are known in considerable detail, although lasting only in the range from seconds to minutes. In contrast, the regulation of lymphocyte migration during transit and exit are not well understood, although these phases last for hours, leaving time for intensive interaction with the extracellular matrix (ecm), fibro-cytes (fc), macrophages (mac), dendritic cells (dc) and various chemokines (ch) and cytokines.

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