Migratory routes of memory lymphocytes

It had been proposed that naive lymphocytes exclusively enter lymph nodes via HEVs (Figure IB), and memory T lymphocytes enter tissues such as the skin and then finally reach the lymph node via afferent lymphatics (Figure 1C). However, the evidence was indirect. More recent in vivo studies using different techniques showed that memory lymphocytes also migrate through HEVs and are found in the efferent lymph. However, it is always problematic to deduce functions from phenotype analysis (as it is necessary to identify naive and memory lymphocytes in migration studies), and therefore the terms naive and memory have to be used with caution. Thus, only when the traffic of marked lymphocyte subsets is followed in vivo is it possible to define the traffic routes used by various lymphocyte subsets.

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