Molecular characterization of IL2

IL-2 belongs to the hematopoietin family which includes growth hormone, prolactin, IL-3, IL-4, IL-5, IL-6, IL-7, IL-9, IL-10, IL-11, IL-13, IL-15, GM-CSF, etc. The IL-2 gene, located on chromosome 4 (q26-q27), contains four exons coding for a 153 amino acid precursor including a 20 amino acid leader sequence. Human IL-2 contains only one O-glycosylation site (Thr3); glycosylation at this site is heterogeneous but does not affect biological activity. The three-dimensional structure of IL-2 is essentially composed of four a helices (A, BB', C and D) connected by three loops (Figure 1). A disulfide bridge between Cys58 and Cysl05 is necessary for the bioactivity of the molecule. The regions of the molecule involved in binding to the three chains of the

B-C Loop

B-C Loop

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book


Post a comment