Mononuclear phagocyte system

Since neither the concept of the reticuloendothelial system nor that of the reticulohistiocyte system provides a fully satisfactory framework into which the current knowledge of phagocytic mononuclear cells can be fitted, the concept of the mononuclear phagocyte system (MPS) was introduced in 1969. This concept is based on what is known about the morphology, function, origin and kinetics of the mononuclear phagocytes. The cells now assigned to the MPS are shown in Figure 1.

Candidate cells for the MPS

Dendritic cells and Langerhans cells are considered as candidates for the MPS because of their bone-

Table 2 Names given to phagocytic cell system

Macrophage system

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