Figure 3 Chemical structures of various MDP derivatives applied to clinical trials.

adjuvanticity but shows no substantial activity regarding nonspecific resistance to infection. Clinical trials using B30-MDP as an adjuvant effect in an influenza virus vaccine demonstrate that it is able to induce both humoral and cellular immunity. MTP-PE has been shown to be highly effective in generating tumoricidal properties of macrophages. Lipo-some-encapsulated MTP-PE (L-MTP-PE) has been designed for in vivo targeting to macrophages and decreasing side-effects, and is in clinical trials for cancer. A series of derivatives replacing the D-isoglut-aminyl residue with D-glutamine alkyl esters of various sizes was shown to be active but much less pyro-genic than MDP. The representative derivative of this series is murabutide, a compound which does not elicit any febrile response in animal experiments.

Clinical trials of murabutide as a vaccine adjuvant and as a potentiator of nonspecific resistance to infection are currently in progress.

Allison and coworkers found that a MDP analog, N-acetylmuramyl-L-threonyl-D-isoglutamine (MDP (Thr)) retained potent adjuvant activity but was less pyrogenic in rabbits and rats. MDP(Thr) has been applied as an immunoadjuvant with the vehicle 'Syn-tex Adjuvant Formulation, SAF', which consists of pleuronic 1.121, squalane, Tween 80 and PBS.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment