Nongranular leukocytes

Vertebrates, and many invertebrates, have evolved a system of internal transport for communicating between components of the immune system. This system comprises the blood and lymph within the circulatory and lymphatic systems. Blood contains two major types of cells: erythrocytes, or red blood cells, and leukocytes, or white blood cells. There are two basic types of leukocytes, nongranular and granular, which play important roles in the immune system. Nongranular (agranular) leukocytes are further divided into two types: lymphocytes and monocytes. Lymphocytes possess receptors for antigens on their surfaces and are thus vital to specific immune responses throughout the body. Like other blood cells, monocytes are produced in the bone marrow and then enter the blood system. They frequently exhibit ameboid movement, and become voracious phagocytes when they leave capillaries and enter connective tissues as macrophages. In adaptive immune responses, macrophages are involved in the presentation of antigens to T cells.

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