Ns

Normal?

A 400 bp deletion preceding Sfi

A short 10 bp deletion

A 70 bp deletion with a 509 bp insertion and another 1.1 kb deletion preceding S|x 1.3 kb deletion with a 57 bp insertion (containing a direct repeat) preceding Sjx

CH1 normal

A large deletion from switch to CH1 leaves its 3' end

A large deletion from Sy to CH1 leaves its 3' end

A large deletion from Sa to CH1 leaves its 3' end

A large deletion from Su- to the

Ch1-Ch2 intron

A large deletion from switch to the Ch1-Ch2 intron

Normal

Normal

Normal

Normal

Normal

A 369 bp deletion 3' to CH3 involving the secreted form a poly (A) site

NS, not sequenced.

region, making this case actually belong to the following group.

3. Most proteins contain an amino-terminal V region fragment of variable length followed by an internal deletion. Some such proteins also contain a sequence corresponding to part of JH and hence have two deletions.

4. A few proteins have an amino-terminal sequence with no homology with any known human sequence.

Most HCD proteins have a high carbohydrate content, with unusual moieties containing gal-actosamine.

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