NSegment and Pnucleotide additions

During V(D)J recombination, the cleavage of the two heptamer elements generates blunt ends, which arc unmodified during ligation to form a heptamer-ro-heptamer signal joint. Coding junctions, however, are heterogeneous in sequence. The recombination process creates many different coding junctions from the same RSS pairs. Nucleotides can be either removed or added enzymatically. Exonucleases can delete residues, while nucleotides can be added at junctions by two different mechanisms. These are

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