Other leukocyte antigens expressed by myeloid cells

Myeloid cells express many other antigens which are not usually considered as myeloid antigens. These include the HLA class I antigens expressed on all myeloid cells except mature red cells and the common leukocyte antigen (CD45) expressed on all leukocytes and early erythroblasts, but not intermediate or late normoblasts. The leukocyte cellular adhesion molecules (Leu-CAMs) or integrins are expressed on granulocytes and monocytes, the CDllb/CD18 complex being heavily expressed on granulocytes and monocytes, and the CDllc/CD18 complex being preferentially expressed on monocytic cells. The phagocyte integrins, in common with CD35 (CR1), CD 15, CD10 and CD13, are stored in intracellular granules and are rapidly unregulated several-fold by a range of stimuli, including C5a, formyl-Met-Leu-Phe, tumor necrosis factor a (TNFa) and granulocyte-macrophage colony-stimulating factor (GM-CSF). All phagocytic cells express the low-affinity

FcyRII (CD32), as do many other cell types, including B cells, some T cells, and some endothelial and epithelial cells. The low-affinity receptor FcyRill (CD16) is expressed on neutrophils and natural killer (NK) cells, and the high-affinity receptor FcyRI (CD64) is expressed on monocytes. FcyRI expression on monocytes is upregulated many-fold by exposure to interferon y (IFNy), and also becomes detectable on neutrophils following interferon treatment.

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