Pals

Central arlery

Trabecular artery

Figure 1 Organization of lymphoid tissue in the spleen. The white pulp is composed of the periarteriolar lymphatic sheaths (PALS) frequently containing germinal centers with mantle zones. The white pulp Is surrounded by the marginal zone. (Marginal zones contain specialized antigen-presenting cells, macrophages and a special subset of B cells.) The red pulp contains venous sinuses separated by splenic cords. Blood enters the tissues via the trabecular artery and becomes the central artery which gives rise to many branches; some end in the white pulp, supplying the germinal centers and mantle zones, but most empty into or near the marginal zones. Some arterial branches run directly into the red pulp, mainly terminating in the cords. The venous sinuses drain blood into pulp veins and then trabecular veins. (Reproduced with permission from Roitt IM, Brostoff J and Male D (eds) (1998) Immunology, 5th edn. London: Mosby.)

Lymphatic nodute

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