Phospholipid antigens

Antiphospholipid autoantibodies are a heterogeneous group of antibodies with specificity to a phospholipid-protein complex. The protein associated with cardiolipin has been identified as a /^-glycoprotein (/32-GPI). Some investigators suggest that this is the relevant autoantigen in patients with antiphospholipid syndrome, although the relative importance of these two molecules has not yet been fully clarified. The most sensitive test used is an ELISA using cardiolipin or other phospholipids to coat ELISA plates. Standardization of the various tests for the different phospholipids has been a problem. However, even so, the clinical utility has been established for antiphospholipid syndrome.

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