Potential clinical significance of IL11

Two clinical trials of IL-11 in cancer patients have been performed. In a phase I trial in patients with breast cancer, IL-11 was administered daily for 14 days during a 28-day prechemotherapy "cycle 0". Patients subsequently received up to four 28-day cycles of cyclophosphamide and doxorubicin chemotherapy (day 1) followed by IL-11 (days 3 through 14). The results indicated that IL-11 has thrombopoietic activity at all doses studied (10, 25, 50, 75 and 100 pg kg-1 day-1), is well tolerated at doses lower than 50 pg kg and at doses greater than 25 |xg kg-' day 1 has the potential to reduce chemotherapy-induced trombocytopenia in these patients. The effects of IL-11 were subsequently evaluated in a ran domized phase II trial in cancer patients who had previously received platelet transfusions for severe chemotherapy-induced thrombocytopenia. Ninety three patients who had received platelet transfusion for nadir platelet counts less than 20 000 pi during chemotherapy cycle immediately prior to entry into the study were randomized to receive placebo or IL 11 at doses of 25 or 50 p,g kg subcutaneouslv once daily for 14 to 21 days beginning one day after chemotherapy. Chemotherapy was continued during the study without dose reduction. The results demonstrated that IL-11 treatment at a dose of 50 pg kg significantly reduces the need for platelet transfusion in subsequent chemotherapy cycles for patients who had required platelet transfusions for severe thrombocytopenia in a previous cycle. The thrombopoietic effect of IL-11 is being further evaluated in other phase II and phase III trials.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment