Recognition of idiotypes by T cells

It is well documented that T cells can recognize the antigenic determinants of immunoglobulins as they are able to recognize foreign, alio or syngeneic antigenic determinants. This was shown for various subsets of T cells, such as suppressor or helper regulatory T cells or effector cells mediating cytotoxic, delayed-type hypersensitivity or contact sensitivity reactions. Anti idiotype T cells can recognize serologically defined idiotypes as well as idiotypes that are not recognized by anti-idiotype antibodies. A regulatory idiotype shared by PC-binding antibodies recognized by T cells but not by anti-idiotype antibodies was identified by Gleason and Kohler. Recent data suggest that the recognition of idiotypes in association with major histocompatibility complex (MHC) antigens requires the processing of native immunoglobulins by antigen-presenting cells in the ease of both CD4 and CD8 T cells.

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