Serotonin and natural killer cells

Natural killer (NK) cell-mediated cytotoxicity against tumor target cells is enhanced by the addition of 5-HT to the incubation mixtures. The stimulation by 5-HT is dependent on the presence of monocytes and is presumably due to the abrogation of the monocyte-induced inhibition of NK activity. These effects are mediated through the 5-HT, receptor, although they were only evident at relatively high concentrations of 5-HT, suggesting that 5-HT may only have a role as an immunomodulator in local host defense against neoplastic cells and microorganisms.

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