CD2 itself has no enzymatic activity but transmits signals in part via the T cell receptor/CD3/£ complex through its interaction with the £ chain and CD3 e and also through other unknown pathways as suggested by the tyrosine phosphorylation of distinct intracellular substrates and the serine dephosphoryl-ation and nuclear translocation of cofilin, a cvclo-sporine-insensitive event. Of particular interest is the interaction of CD2 with the tyrosine phosphatase CD45. CD2 also interacts with the tyrosine kinases p56kk, P59""1 and the f subunit of the T cell receptor/CD3/f complex, each of which have been shown to be targets for CD45 phosphatase activity. Indeed it is possible that CD2 regulates T cell activation by bringing CD45 into the proximity of these molecules.

Perturbation of CD2 and/or its associated signaling molecules provides a means for positively and negatively regulating T cell responses and may turn out to represent a central component of therapeutic efforts to regulate tolerance.

See also: Adhesion molecules; CD45 (the leukocyte common antigen); Cell-mediated lysis; Lymphocyte function-associated antigen 3 (LFA-3); T lymphocyte activation; T lymphocyte differentiation.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment