Signaling

CD2 itself has no enzymatic activity but transmits signals in part via the T cell receptor/CD3/£ complex through its interaction with the £ chain and CD3 e and also through other unknown pathways as suggested by the tyrosine phosphorylation of distinct intracellular substrates and the serine dephosphoryl-ation and nuclear translocation of cofilin, a cvclo-sporine-insensitive event. Of particular interest is the interaction of CD2 with the tyrosine phosphatase CD45. CD2 also interacts with the tyrosine kinases p56kk, P59""1 and the f subunit of the T cell receptor/CD3/f complex, each of which have been shown to be targets for CD45 phosphatase activity. Indeed it is possible that CD2 regulates T cell activation by bringing CD45 into the proximity of these molecules.

Perturbation of CD2 and/or its associated signaling molecules provides a means for positively and negatively regulating T cell responses and may turn out to represent a central component of therapeutic efforts to regulate tolerance.

See also: Adhesion molecules; CD45 (the leukocyte common antigen); Cell-mediated lysis; Lymphocyte function-associated antigen 3 (LFA-3); T lymphocyte activation; T lymphocyte differentiation.

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