Sources of IL3

The major physiological sources of IL-3 appear to be T lymphocytes and, in the human, natural killer (NK) cells. IL-3-dependent mucosal mast cells, connective tissue mast cells and eosinophils also produce small amounts of IL-3 when they are stimulated, for example, by crosslinking of antibodies bound to Fc receptors on their surface. IL-3 released during allergic reactions may affect the functions of mast cells and eosinophils as well as those of other cells such as macrophages. There is no evidence that any of the stromal cells of the bone marrow normally produce IL-3.

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