Structure of LIF

The characterization of the LIF molecule is summarized in Table 2. The structure of murine LIF, as determined by X-ray crystallography, affiliated LIF to the hematopoietic cytokine family. It is composed of an a helix bundle structure, previously observed for several members of this cytokine family. A variant of murine LIF, derived by alternative splicing of signal sequence exons, is targeted to the extracellular matrix.

Table 2 Structural characteristics of LIF
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