Studies on the immune response

It is generally assumed that the extremely diverse HLA system evolved in response to the increasing variety of microorganisms against which an immune response is required. Extensive studies are underway to define the peptides which 'fit' into the groove of the HLA molecule. Certain peptides are shown to fit into the groove of certain HLA alleles but not others. This contact is thought to be a critical step in the immune response, accounting for the fact that some individuals in one species are resistant to a microbe while others are not. Even the response to cancer antigens is thought to be controlled by the HLA specificity present in the patient.

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