Susceptibility to replicative L. pneumophila lung infection is determined by the permissiveness of host MPCs to the intracellular growth of the bacteria. These bacteria grow within macrophages and protozoa by avoiding phagolysosomal fusion and by trafficking to a permissive endosome that associates with the host ER. Intracellular growth is controlled both by genetic factors and by the state of MPC activation. Survival of susceptible hosts after primary replicative L. pneumophila infections depends on cellular immune mechanisms, including the release of IFNy. Acquired immunity to L. pneumophila is probably the result of a coordinated response between humoral and cellular immune responses, which facilitates enhanced uptake of the bacteria by activated MPCs.

See also: Bacteria, immunity to; Bacterial cell walls; Phagocytosis; Respiratory and cardiac infections.

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