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Figure 2 IL-7 signal transduction pathway. Molecules involved in IL-7 signal are depicted schematically. With respect to genes for which mice or human that bear null mutation are available, the phenotypes are given in the corresponding box.

cell proliferation is as yet unclear. Recent studies to reconstitute the IL-7Ra signal of IL-7Rct( —) pro-B cells by transfecting the receptor genes bearing various mutations indicates that STAT recruitment is not sufficient for the induction of pro-B to pre-B differentiation.

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