TGFp and experimental infectious diseases

The immunoregulatory effects of TGFp, and TGFp> have been assessed in mice infected with lymphocytic choriomeningitis virus (LCMV). Intraperitoneal injections of 1 pg per day of recombinant TGFp, and TGFp, prolonged the survival interval after LCMV infection, inhibited the footpad swelling after local LCMV infection and impaired clearance of LCMV in infected mice. In Borna disease, a sporadically occurring progressive encephalopathy of sheep and horses that can be induced in a wide range of animal species by infection with Borna virus, a single-stranded RNA virus, TGF(3 inhibited clinical disease and reduced the inflammatory reaction and MHC class II expression in the brain and the production of antibodies to the virus.

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