The Hanganutziu Deicher HD system

H-D antibodies were first described under the name 'serum sickness antibodies' by Hanganutziu in 1924, and then by Deicher in 1926 in patients who received injections of sera of foreign species origin administered for serum therapy. Subsequently, H-D antibodies were found in human sera from many pathological conditions, though usually in low frequencies. H-D antigen is found in the tissues of all mammals studied to date, but it is absent from normal human tissues. On the other hand, it has been demonstrated in some human pathologic tissues, notably lymphoma and melanoma. Chemically, H-D antigen is an N-glycolylneuraminic acid, but many H-D-posi-tive human sera contain antibodies combining with other antigenic moieties found in the high molecular weight glycoprotein fraction of sheep and bovine erythrocytes. Serologically characteristic is the disappearance of agglutination of sheep erythrocytes after absorption of sera containing H-D antibodies with bovine red blood cells as well as with guinea pig kidney suspension.

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