The MIF gene

At one time it was proposed that there is a multigene family for MIF-like proteins, which might help to explain the diversity of properties described. However, it is now clear that the human genome contains only a single gene for MIF, which has been cloned, sequenced and mapped to chromosome 22qll.2. The human gene for MIF is remarkably small for an intron-containing gene; three exons and two introns occupy only 800 bp. In mouse, similarly, there is a single, functional gene on chromosome 10. However, in contrast to human, the mouse genome also contains multiple processed pseudogenes.

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