Tm

CYTO a.a. 451-881

wsxws Motifs

Acid-rich domain gp 130 homology domain

Figure 4 Structure of the human IL-3 ßc subunit: EC, extracellular domain; TM. transmembrane domain; gp130 homology domain, region containing the i) Pro-Asn-Pro motif that is important for tyrosine phosphorylation and cell proliferation, and ii) acid-rich domain containing 11 acidic and 1 basic amino acids which comprise a motif shared with the p75 signaling subunit of the IL-2 receptor. The membrane-proximal domain, extending between Arg456 and Asp544 is involved in mediating the proliferative signal through the IL-3 receptor. A region encompassing amino acids Val518 to Leu626 is responsible for major tyrosine phosphorylation, and the membrane-distal region (Leu626-Ser763) is required for activation of Ras, Raf-1, MAPK, and p70 S6K. as well as induction of c-fos and c-jun.

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