CYTO a.a. 451-881

wsxws Motifs

Acid-rich domain gp 130 homology domain

Figure 4 Structure of the human IL-3 ßc subunit: EC, extracellular domain; TM. transmembrane domain; gp130 homology domain, region containing the i) Pro-Asn-Pro motif that is important for tyrosine phosphorylation and cell proliferation, and ii) acid-rich domain containing 11 acidic and 1 basic amino acids which comprise a motif shared with the p75 signaling subunit of the IL-2 receptor. The membrane-proximal domain, extending between Arg456 and Asp544 is involved in mediating the proliferative signal through the IL-3 receptor. A region encompassing amino acids Val518 to Leu626 is responsible for major tyrosine phosphorylation, and the membrane-distal region (Leu626-Ser763) is required for activation of Ras, Raf-1, MAPK, and p70 S6K. as well as induction of c-fos and c-jun.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment