TNFa and interferon y (IFN7) are more sensitive parameters in mixed lymphocyte culture than proliferation and may be possible prospective parameters in bone marrow and organ transplantation. Graft-versus-host disease significantly correlates with enhanced TNFa, but not IL-1 and IL-6 serum levels in bone marrow recipients, even in transplantation of bone marrow from siblings. During acute graft rejection of organs, there is an increase in plasma levels of TNFa. In heart transplantation TNFd3 (associated with high production of TNFa) seems to be a risk factor, whereas the -308 polymorphism is of no relevance, because this promoter region is negatively regulated by cyclosporine. During kidney rejection there are increased TNFa levels resulting from an imbalance between TNFa and sTNFR, which is not observed during cyclosporine nephrotoxicity. In a rat model, anti-TNFa treatment extends allograft survival. This effect is enhanced by a combination of anti-TNFa and anti-IFNy.

How To Bolster Your Immune System

How To Bolster Your Immune System

All Natural Immune Boosters Proven To Fight Infection, Disease And More. Discover A Natural, Safe Effective Way To Boost Your Immune System Using Ingredients From Your Kitchen Cupboard. The only common sense, no holds barred guide to hit the market today no gimmicks, no pills, just old fashioned common sense remedies to cure colds, influenza, viral infections and more.

Get My Free Audio Book

Post a comment