The prophylactic use of antimicrobial agents, in particular co-trimoxazole (a compound of trimethoprim and sulphamethoxazole) has transformed the natural history of this condition from one of frequent, life-threatening infections to that resulting in an almost normal life.

Infections that do occur must be treated aggressively with antimicrobial agents. Infusions of neutrophils should be used in addition in severe or systemic infection.

See also. Granuloma; Macrophage activation; Microbicidal mechanisms, oxygen-dependent; Neutrophils; Phagocytosis; Staphylococcus, infection and immunity.

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