Derek Wakelin, Department of Life Science, University of Nottingham, Nottingham, UK

Trichuriasis is caused by infection with the nematode Trichuris trichiura, one of a group of worms, the soil-transmitted nematodes, that includes some of the commonest parasites of humans. Globally, some 800 million people harbour T. trichiura. The existence of such widespread and long-term infections raises a number of interesting questions about host resistance and susceptibility, some of which have been answered by studies in laboratory models.

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