Ungulate immunoglobulins

Ungulate immunoglobulins have been identified and classified according to their analogy with immunoglobulins in other species on the basis of similarities in amino acid sequence, immunological cross-reaction, physicochemical properties and biological function. In sheep and cattle, the most widely studied of the ruminant species, analogs of IgG, IgM, IgA and IgE have been identified, with structure and function characteristics as defined in Table 1. In contrast to other species there are only two subclasses of IgG, designated IgGl and IgG2, and, also in contrast to other species, IgA in serum exists predominantly as a dimer, originating from IgA plasma cells at mucosal surfaces rather than from bone marrow.

For many years controversy persisted over the nature of the reaginic or homocytotrophic antibody (i.e. the analog of IgE) in ruminants, with some evidence supporting the existence of a minor IgG subclass accounting for these effects. However, more recent work has clearly revealed the existence of a true IgE isotype which can be identified by mono

Structure Complement Serum half-life Sedimentation fixation (days) coefficient

Pentameric with J chain + 6 19

Dimeric - 3 10

Dimeric with J chain - 11

Monomeric

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