Veneered antibodies

An alternative method of humanization is described as veneering or resurfacing and aims to replace the surface exposed amino acid residues on the rodent monoclonal with corresponding residues from a closely matched human antibody. Computer graphic modeling of the rodent monoclonal is used to identify these surface residues which are unlikely to be involved in maintaining the correct conformation of loops. These are then substituted. The method has not been widely used. A few examples have been described, although no clinical data is available as yet.

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