References

A resume of the literature on inosite phosphoric acid with special reference to the relation of that substance to plants. Biochem. Bull. 2 21-49. 2. Averill, H.P. and King, C.G. 1926. The phytin content of foodstuffs. J. Amer. Chem. Soc. 48 724-728. 3. Harland, B.F. and Oberleas, D. 1987. Phytate in foods. World Rev. Nutr. Diet. 52 235-259. 4. Reddy, N.R., Pierson, M.D., Sathe, S.K., and Salunkhe, D.K. 1989. Phytates in Cereals and Legumes. CRC Press, Inc., Boca Raton, FL. 5....

Antioxidant Properties Of Inositol Phosphates In Vivo

A question that remains is whether this antioxidant property of phytate might function in vivo, and whether it mediates the potential disease-sparing characteristics of phytate that have been observed in cancer studies 10 . To test this hypothesis, researchers have used cells in culture or animal models and measured the ability of phytate to attenuate the oxidative stress induced by various means. To date, the literature on this question is equivocal, with some studies indicating that InsP6...

Dietary Intake Of Phytate

Estimates of phytate daily intake in different parts of the world are presented in Table 3.8. These estimates are compiled from various nutritional studies based on different methods of data collection and analysis. Harland and Peterson 199 suggested that the average American (weighing 75 kg) consumes about 750 mg phytate per day. However, several studies 200-203 conducted in the United States indicate a wide variation in daily intake of phytate (Table 3.8). These variations could be due to...

Degradation Of Phytate In The Colon

The phytase level of microbial origin is very low in the small intestine of mammalians 71 . Considering the large number of microorganisms present in the colon, degradation of phytate by microbial phytase could be expected to occur in the colon. The germ-free animal would be a useful model with which to investigate the extent of phytate degradation by microbial phytase in vivo. In a study by Wise and Gilburt 72 , the hydrolysis of phytate was compared in germ-free and conventional rats. In...

Possible Mechanisms Of Anticancer Effects

Because PA is ubiquitous to every mammalian cell, it is not surprising that it has a cancer protective effect on different tissues, in different experimental models and under various conditions. However, the mechanisms of PA action are not clear and are open to conjecture. Many of the proposed mechanisms of PA action are related to its structure and its physical properties (Figure 14.3). For example, PA may potentially bind important proteins and enzymes, either within the cell or in the...