on-on on-off off-on

FIGURE 20.5 Contrasts and similarities between L-Dopa and DBS effects on temporal memory distortions in PD. Accuracy of subjective time estimates in PD groups trained and tested with the encode-decode design either ON and OFF DA supplementation (left panel) or ON and OFF DBS (right panel) in the STn. Accurate estimates are seen ON L-Dopa during both training and testing sessions, whereas estimates are rightward shifted with stimulator ON. Duration-dependent errors (migration), however, are similarly alleviated by drug replacement and functional surgery treatments. Slowed encode is revealed in both OFF-ON L-Dopa and DBS groups during testing, and the magnitude of the effect seems quite similar between these two groups, although reliably reduced in the presence of feedback during training, stimulator ON.

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