Convergence Of Pyrogenic Mechanisms

There is some convergence in the understanding of host mediator activation that includes microbial cell envelope components including LPS, PG, secreted toxins (including the streptococcal pyrogenic exotoxins), and enterotoxins (Staphylococcus). The modes of activation of host defenses overlap in some cases. Although endo-toxin is the most potent in its activity (i.e., active at the lowest concentrations), it

TABLE 3 Known and Suspected Human Diseases Caused by Superantigens

Superantigens and pyrogenic exotoxins

Food-borne

Non-staph and Non-strep SAg

Emerging pathogens

Staphylococcus:

Clastridium

Mycoplasma

Spirochetes'

TSSa (SAg: TSST-1)

perfringens

lipopeptides and

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