Changes in the delivery to the tissues of a normal amount of blood containing the proper amount of electrolytes, nutrients, and oxygen at the proper pressure can result in damage. Infarction is necrosis of tissue due to interruption of the blood supply, usually due to atherosclerosis. Myocardial (heart) and pulmonary (lung) infarcts are often immediately fatal, but they may heal, often with scarring and impaired function. There is considerable paleopathologic evidence of atherosclerosis and Egyptian tomb paintings give evidence of acute myocardial infarction, but experimental studies show that the necrosis of an acute infarct is indistinguishable from postmortem autolysis and thus probably undiagnosable.
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