Sexlinked Inheritance

X-linked Inheritance. The key feature of the X-linked mode is that males and females are affected disproportionately. X-linked genes are transmitted in either a monogenic dominant or recessive mode of inheritance. Females can be either homozygous or heterozygous for X-linked traits, whereas normal males are always hem-izygous for loci located on the X chromosome.

Y-linked Inheritance. The key feature of the Y-linked mode is that only males carry the gene. Y-linked inheritance is displayed by genes located on the non-recombinant region of the Y chromosome. Normal females never possess a Y chromosome, and normal males are always hemizygous for the Y chromosome. Absence of the SRY gene on a Y chromosome, through either mutation or crossing-over (to an X chromosome), results in a condition known as the XY female syndrome.

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