Examples Of Proven Laboratory Interventions

The delayed-senescence extended-longevity phenotype has been induced successfully in laboratory animals as a result of genetic interventions designed to decrease oxidative stress and/or alter the energy metabolism of the organism.

Decreasing oxidative stress. People need oxygen. Without it, human beings cannot generate enough energy to live and quickly die. However, the oxygen that keeps people alive is a double-edged sword, for it also can break down within the cell to yield highly chemically reactive molecules of various kinds that are termed collectively reactive oxygen species (ROS) or, less accurately, free radicals. These ROS chemically combine with any of the cell's components and transform them into oxygen-based damage products, a process referred to as oxidative stress. In lay terms, one might envision the cell undergoing something akin to self-perpetuating rusting.

Organisms have within them a very elaborate system with which to defend themselves against the depredations of oxidative stress. That system seems to be reasonably effective at getting rid of most (but not all) of the ROS molecules that are generated in young animals and thus keeping the level of oxidative stress to a low (but measurable) level. But even this low level of oxidative stress causes some damage, which accumulates. Eventually the failure to repair completely causes increasing inefficiencies in the body's ADS. This then allows the rate of oxidative stress and cell damage to increase at a compound rate, and the age-related loss of function soon

How To Add Ten Years To Your Life

How To Add Ten Years To Your Life

When over eighty years of age, the poet Bryant said that he had added more than ten years to his life by taking a simple exercise while dressing in the morning. Those who knew Bryant and the facts of his life never doubted the truth of this statement.

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