It is now possible to map transcription factor binding sites across entire genomes of organisms with small genomes and many segments of the human genome. With higher density arrays becoming available through arrays constructed using photolithography (Affymetrix and Nimblegen) it will likely be possible to carry out whole human genome analysis of transcription factor binding using ChlP-chip. The use of these arrays for the analysis of the 1500-2000 mammalian transcription factors in many cell types will provide a transcriptional circuitry for mammalian development and cell function.

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