The analysis of genomic copy number aberrations and chromosomal rearrangements using large insert clone DNA microarrays is becoming an increasingly widespread application. The development of chromosome specific or whole genome-wide tiling path arrays, as well as arrays consisting of clones with inserts of even smaller size such as fosmids or PCR products, will allow the detection of increasingly subtle genomic changes to be identified by this technology. Thus, microarray analysis will facilitate the identification of new genes involved in tumor development and progression, as well as genes contributing to cytogenetically important syndromes and previously undiagnosed cases.

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