Leading Causes of Death

Figure 10.1 illustrates mortality patterns for non-Hispanic white females in the United States for the years 1999 and 2000. The top row of panels shows the age-specific death rate per 100,000 individuals on a log-log scale. The columns plot all causes of death, death by heart disease, and death by cancer. The curves for death rate in the top row have different shapes. To study quantitative characteristics of death rates, it is useful to present the data in a different way. The second row of...

Alternative Pathways to Colorectal Cancer

Approximately 15 percent of colorectal tumors do not have CIN or widespread chromosomal abnormalities Rajagopalan et al. 2003 . Instead, these tumors usually have mutations in their mismatch repair MMR system, a component of DNA repair Boland 2002 . Loss of MMR Figure 3.3 Genetic changes in HNPCC progression. Approximately 2-4 percent of colorectal cancers follow this pathway. Figure 3.3 Genetic changes in HNPCC progression. Approximately 2-4 percent of colorectal cancers follow this pathway....