Bile acid sequestering agents resins

This class of agents was first developed for the treatment of cholestasis-related pruritus by Carey and Williams in 1960. Hashim and Van Itallie subsequently demonstrated that cholestyramine lowered plasma cholesterol and it has been in clinical use for 30 years. Other agents in this class are colestipol and the recently approved colesevelam. The enterohepatic circulation of bile acids allows for only 6 or 7 of them to be excreted each day. These polymers with a molecular weight of over 106 are...