A A A

DQA1*040101 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*040102 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*0402 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*050101 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*050102 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*0503 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*0504 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*0505 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*060101 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

DQA1*060102 ----T----T-T -T-----TT C-- --A C-----A-- ...-----------A

Antisense Sense

Fig. 1 (a) Low-resolution probes for the typing of HLA-DQA1*02 and HLA-DQA1*03 alleles: a region of the HLA-DQA1 gene showing variations in the sequence for each allele. Probe sequences are shown by either a light bar (sense probe) or a dark bar (antisense).

Fig. 1 (Continued next page) (b) Low-resolution probes for the typing of HLA-DQA1*01 alleles: a region of the HLA-DQA1 gene showing variations in the sequence for each allele. Probe sequences are shown by either a light bar (sense probe) or a dark bar (antisense). (c) Low-resolution probes for the typing of HLA-DQA1*05, HLA-DQA1*04/HLA-DQA1*06 alleles: a region of the HLA-DQA1 gene showing variations in the sequence for each allele. Probe sequences are shown by either a light bar (sense probe) or a dark bar (antisense). (View this art in color at www.dekker.com.)

software that implements (1)-(4) above and searches out the ideal placement of the probe along the sequence of the gene. Produce amine-modified probes by means of a standard phosphoramidite and segmented synthesis strategy for the simultaneous synthesis of a large number of oligonucleotides.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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