Fig. 1 Map of the sites of several hundred small mutations in TSC1 and TSC2. Proportional drawings (boxes) of all of the exons of TSC1 and TSC2 are shown. Intron regions are not drawn to scale and are expanded only when a mutation is present. Mutation symbols are: x , nonsense; ■, splice site; A, deletion; V, insertion; O, missense; □, in-frame deletion. A line separates mutations occurring at nearby but not identical nucleotide positions.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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