Aat Replacement Therapy

The potential to treat lung disease by replacement to augment the lung antiprotease protective screen is available either by the intravenous route or by inhalation

Fig. 3 A diagrammatic representation of the structure of the AAT gene. The coding exons are dark-shaded; untranslated exons are in lighter shade; and the location of tissue-specific promoters and a 3' enhancer is also shown.

through the nasal route. Early studies (by Gadek et al.[15]) demonstrated that intravenous administration of AAT was feasible and biochemically effective. Studies have shown that aerosol administration too is effective.[16]

Although these studies demonstrate biochemical efficacy, it is not yet known whether they influence the outcome of the chronic respiratory disease associated with AAT deficiency. In a large study undertaken in the United States, 1129 subjects with severe AAT deficiency were monitored for 3.5-7 years. The 5-year mortality rate was 19%. The mortality rate was lower in those receiving augmentation therapy,[17] suggesting that long-term replacement therapy may be beneficial. There are anecdotal reports of successful treatment of panniculitis arising from AAT deficiency.

a limitation of the tests, as rare variants may be falsely reported as normal, and the use of serum AAT measure- _ ^ ments minimizes this likelihood, but does not completely exclude it. DNA-based tests do offer a robust and reliable method for detecting the common S and Z alleles.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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