Ank2 Lqt4

As of today, only one family linked to this locus (4q25-q27) has been reported.[5] Of note, the phenotype of the LQT4 patients differs from the typical LQTS. Most of the affected individuals, besides QT interval prolongation, also present with severe sinus bradycardia, paroxysmal atrial fibrillation (detected in >50% of the patients), and polyphasic T waves. Recently, a missense mutation in the ANK2 gene was identified in this family.[9] ANK2 encodes for an intracellular protein (ankyrin) that regulates the proper intracellular localization of plasmalemmal ion channels (calcium channel, sodium channel, sodium/ calcium exchanger), sarcoplasmic reticulum channels

(ryanodine receptor, inositol triphosphate receptor), and other adhesion molecules.[18]

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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