Annotation Migration

Example 2: from newly published Genbank data to genome annotation.

Chumakov et al.[15] reported association between G72 gene and schizophrenia. In this paper, 191 SNPs and two novel genes (G72 and G30) on chromosome 13 were reported. Most of these data could not be found in public annotation. Chumakov et al. deposited a series of Genbank format sequence data for chromosome 13 fragments. DNannotator was used to migrate annotations from these fragments to public assembly of chromosome 13 to find out how these SNPs and genes are mapped on human chromosome 13 and how these SNPs and genes related to the other SNPs and genes. As an example, AE014312 is one of the Chumakov's deposit with 250-kb sequence and contains 20 SNPs, 2 genes, and 1 STS. DNannotator takes this input and produced annotation on human public assembly chromosome 13. All features (SNPs, genes, and STSs) were mapped to chromosome 13

in one step. The GFF format data are viewed in Genome Browser as in Fig. 3. In this figure, we can view all annotations provided by Chumakov's group with all the other data created by public annotation.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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