Application To Physiological Effects

To understand biochemical alterations caused by disease, it is necessary to understand any underlying physiological sources of variation. Metabonomics has been used to determine the metabolic differences in cohorts of normal subjects and control laboratory animals. Many effects can be distinguished and characterized using meta-bonomics, including male/female differences, age-related changes, estrus cycle effects, diet, diurnal effects, inter-species differences and similarities, and the effects of gut microflora.[9]

Metabonomics has also been used for the phenotyping of mutant or transgenic animals that model human diseases and the investigation of the consequences of transgenesis such as the transfection process.[9] Metabo-nomic approaches can give insight into the metabolic similarities or differences between mutant or transgenic animals and the human disease processes that they are intended to simulate and hence their appropriateness for monitoring the efficacy of novel therapeutic agents.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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