Autosomal Recessive FDCM

Autosomal-recessive FDCM is rare and cosegregates with skeletal myopathies. Mutations in four genes have been identified. A homozygous LMNA mutation was identified in autosomal-recessive Emery-Dreifuss muscular dystrophy (AR-EDMD).[14] SGCB encodes p-sar-coglycan, a component of the sarcoglycan complex linking the extracellular matrix to the dystrophin. Mutations in FKRP were identified in two allelic disorders: a form of limb girdle muscular dystrophy (LGMD2I) and a form of congenital muscular dystrophy (MDC1C). FKRP encodes the fukutin-related protein, a newly identified protein implicated in glycosylation of a-dystroglycan, another component of the DCG complex.1-15,16-1 Mutations in DSP, encoding desmoplakin, a protein of the desmosome complex, cause DCM associated with wooly hair and keratoderma.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

Get My Free Ebook


Post a comment