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Genotype-Phenotype Correlations in Cowden Syndrome

PTEN mutations have also been found in up to 60% of patients with BRR[10] and in some patients with hamartomas that carried the diagnosis of other conditions, namely, LDD,[19] PS or PS-like syndromes,[20] and VATER association Proteus.[21] Identical, as well as distinct, PTEN mutations have been found in all of these syndromes.

Preliminary genotype-phenotype correlations have been identified in CS. Firstly, in CS families (or CS/ BRR overlap families), the presence of a PTEN mutation has been correlated with the presence of any cancer, lipomas, or breast fibroadenoma.[10] An association between the presence of a PTEN mutation and breast involvement, whether it be benign or malignant disease, has also been observed.[10] A study of a large number of CS families representing multiple ethnicities is required in order to confirm these findings.

Getting Started With Dumbbells

Getting Started With Dumbbells

The use of dumbbells gives you a much more comprehensive strengthening effect because the workout engages your stabilizer muscles, in addition to the muscle you may be pin-pointing. Without all of the belts and artificial stabilizers of a machine, you also engage your core muscles, which are your body's natural stabilizers.

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